We’re here to help
Kedrion Connects™ provides access assistance, financial support, resources, and training to help patients and caregivers navigate treatment with confidence.
Patient and Caregiver
Education & Training
A Kedrion Nurse Educator will help you*:
- Learn RYPLAZIM proper reconstitution, administration, and safe handling
- Better understand PLGD-1 and its treatment
- Connect with resources, such as patient groups and advocacy organizations
- Learn how to self-infuse if your doctor has approved you for at-home infusions
Patient
Support
- Insurance benefit and drug coverage verification
- Prior authorization navigation
- Financial assistance for eligible copays
- Navigate insurance changes
Financial
Assistance
The RYPLAZIM Copay Assistance Program offers financial support to help with your deductible, copay, and/or coinsurance for RYPLAZIM.
Some restrictions apply.
See if you’re eligible*Information from a Kedrion Nurse Educator should not replace your physician’s advice
Enroll in Kedrion Connects
Ask your doctor or pharmacy to complete both the New Start and Patient Consent Form to be enrolled in Kedrion Connects. Have your doctor return completed forms to MedMonk:
Phone: 888-262-8040Fax: 408-419-1768
KedrionConnects
Form
Resources
Connect with the community
Connect with the Plasminogen Deficiency Foundation to
- Learn more about PLGD-1
- Access resources
- Connect with a patient ambassador
The National Organization for Rare Disorders is a trusted nonprofit dedicated to improving the lives of people living with rare diseases.
- Explore support programs, clinical trial information, rare disease stories, and more
Join the Insight Forum to
- Participate in an in-person seminar
- Engage with other families impacted by PLGD-1
- Share your PLGD-1 journey, stories, and insights
- Learn from others impacted by PLGD-1
Real patient stories
Diagnosed with PLGD-1: 6 months old
Years of RYPLAZIM: 6
Interests: Playing tennis, building legos, and playing video games
Diagnosed with PLGD-1: 2 years old
Years of RYPLAZIM: 2
Interests: Playing soccer, reading, and baking
Diagnosed with PLGD-1: 2 years old
Years of RYPLAZIM: 1.5
Interests: Karate, painting, family movie nights, and anything outdoors
Diagnosed with PLGD-1: 15 years old
Years of RYPLAZIM: 1.5
Interests: Writing and playing volleyball
APPROVED USE
RYPLAZIM® (plasminogen, human-tvmh) is used for the treatment of patients with plasminogen deficiency type 1 (hypoplasminogenemia).
IMPORTANT SAFETY INFORMATION
Do not use RYPLAZIM if you are a patient with known hypersensitivity to plasminogen or other components of RYPLAZIM.
- Bleeding: Use of RYPLAZIM may lead to bleeding at disease-related lesion sites or worsen active bleeding not related to disease lesions. Discontinue RYPLAZIM if serious bleeding occurs. If you are treated at a healthcare provider’s office or center, your healthcare provider will need to monitor you during the infusion and for 4 hours afterward, especially if you have a predisposition to bleeding or are taking anticoagulants, antiplatelet drugs, or other medications that may interfere with normal coagulation. If you infuse RYPLAZIM at home, you or your caregiver must also monitor you during and for 4 hours after the infusion under the same circumstances.
- Tissue Sloughing: If you have mucosal lesions in your respiratory tract, especially the tracheobronchial tree, and are treated with RYPLAZIM, respiratory distress may occur due to tissue sloughing. Please monitor appropriately.
- Transmission of Infectious Agents: RYPLAZIM is made from human plasma and therefore carries a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and theoretically, the Creutzfeldt-Jakob Disease (CJD) agent. You should consult with your healthcare provider if you have any questions or concerns.
- Hypersensitivity Reactions: Hypersensitivity reactions, including anaphylaxis, may occur with RYPLAZIM. Immediately report any of the following signs or symptoms of an allergic reaction to your healthcare provider: swelling of the throat, tightness of the chest, low blood pressure, rash, nausea, vomiting, a tingling or pricking sensation, restlessness, wheezing or shortness of breath.
- Neutralizing Antibodies: Antibodies neutralizing plasminogen (also known as inhibitors) which can make the product less effective or ineffective, may form with the use of RYPLAZIM, although they were not observed in clinical trials. If clinical efficacy is not maintained (e.g., development of new or recurrent lesions), your healthcare provider will determine low levels of plasminogen in your plasma.
- Laboratory Abnormalities: Due to the activity of RYPLAZIM, you may have elevated blood levels of D-dimer that may interfere with screening for venous thromboembolism (VTE) using D-dimer levels.
- Adverse Reactions: The most frequent (incidence ≥ 10%) adverse reactions in clinical trials were abdominal pain, bloating, nausea, fatigue, extremity pain, hemorrhage, constipation, dry mouth, headache, dizziness, arthralgia, and back pain.
You may report side effects to 1 (855)-353-7466 and US_Medicalinfo@kedrion.com or FDA at 1 (800)-FDA-1088 or www.fda.gov/medwatch.
For more details, please see full Prescribing Information and the Patient Information.
This site is intended for residents of the US only.