https://www.ryplazim.com/ 1.0 https://www.ryplazim.com/assets/images/plasminogen-replacement-therapy.png RYPLAZIM plasminogen replacement therapy https://www.ryplazim.com/assets/images/plasminogen-deficiency-etiology-graphic.png Plasminogen deficiency etiology graphic https://www.ryplazim.com/assets/images/community_image.png Plasminogen deficiency type 1 patient community https://www.ryplazim.com/assets/images/riley_sphere.png Ryplazim patient, Riley https://www.ryplazim.com/about-ryplazim/how-to-use-ryplazim/ 0.9 https://www.ryplazim.com/assets/images/about/using/blue-uparrow.png Graphic showing RYPLAZIM boosts low plasminogen levels https://www.ryplazim.com/cost-support-resources/ligneous-conjunctivitis-gallery/ 0.9 https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-caused-by-congenital-plasminogen-deficiency-type-1.png Ligneous conjunctivitis caused by congenital plasminogen deficiency type 1, manifesting as an eye lesion, prior to treatment with RYPLAZIM https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-with-lesion-similar-in-appearance-to-conjunctival-papilloma.png Ligneous conjunctivitis with lesion similar in appearance to conjunctival papilloma https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-upper-eyelid-swelling.png Ligneous conjunctivitis manifesting as upper eyelid swelling https://www.ryplazim.com/assets/images/gallery-pseudomembranous-conjunctivitis-caused-by-plasminogen-deficiency-type-1-with-a-watery-and-stringy-appearance.png Pseudomembranous conjunctivitis caused by plasminogen deficiency type 1, with a watery and stringy appearance https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-with-multiple-white-cauliflower-like-lesions-in-upper-and-lower-eyelids.png Ligneous conjunctivitis with multiple white, cauliflower-like lesions in upper and lower eyelids https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-white-lesions-in-lower-eyelid.png Ligneous conjunctivitis manifesting as white lesions in lower eyelid https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-a-lesion-under-the-upper-eyelid.png Ligneous conjunctivitis manifesting as a lesion under the upper eyelid https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-with-lesions-behind-the-upper-and-lower-eyelids.png Ligneous conjunctivitis with lesions behind the upper and lower eyelids https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-a-wart-like-growth.png Ligneous conjunctivitis manifesting as a wart-like growth in the lower eyelid, accompanied by upper eyelid swelling https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-accompanied-by-swelling.png Ligneous conjunctivitis accompanied by swelling https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-lesions-and-swelling.png Ligneous conjunctivitis manifesting as lesions and swelling https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-a-yellow-discharge-in-the-lower-eyelid.png Ligneous conjunctivitis manifesting as a yellow discharge in the lower eyelid https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-wood-like-growth-under-eye.png Ligneous conjunctivitis manifesting as wood-like growth under eye https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-large-white-mass-under-eyelid.png Ligneous conjunctivitis manifesting as large white mass under eyelid https://www.ryplazim.com/assets/images/gallery-ligneous-conjunctivitis-manifesting-as-large-masses-under-upper-and-lower-eyelids.png Ligneous conjunctivitis manifesting as large masses under upper and lower eyelids https://www.ryplazim.com/assets/images/gallery-ligneous-gingivitis-periodontitis-with-gingival-enlargement.png Ligneous gingivitis (periodontitis) with gingival enlargement https://www.ryplazim.com/assets/images/gallery-ligneous-gingivitis-in-the-upper-left-mouth.png Ligneous gingivitis in the upper left mouth https://www.ryplazim.com/assets/images/gallery-ligneous-gingivitis-caused-by-plasminogen-deficiency-type-1.png Ligneous gingivitis caused by congenital plasminogen deficiency type 1, manifesting as gum lesions https://www.ryplazim.com/assets/images/gallery-ligneous-gingivitis-with-gum-swelling-and-lesions.png Ligneous gingivitis with gum swelling and lesions https://www.ryplazim.com/assets/images/gallery-ligneous-periodontitis-gum-swelling.png Ligneous periodontitis gum swelling https://www.ryplazim.com/assets/images/gallery-skin-lesions-on-arm.png Skin lesions on arm https://www.ryplazim.com/assets/images/gallery-skin-lesions-on-hand.png Skin lesions on hand https://www.ryplazim.com/assets/images/gallery-skin-lesions-on-back.png Skin lesions on back https://www.ryplazim.com/assets/images/gallery-skin-lesions-on-thumb.png Skin lesions on thumb https://www.ryplazim.com/assets/images/gallery-skin-lesions-on-palm-of-hand.png Skin lesions on palm of hand https://www.ryplazim.com/assets/images/gallery-respiratory-tract-lesions-in-plasminogen-deficiency-type-1-patient.png Respiratory tract lesions in plasminogen deficiency type 1 patient https://www.ryplazim.com/assets/images/gallery-otological-lesions-in-plasminogen-deficiency-type-1-patient.png Otological lesions in plasminogen deficiency type 1 patient https://www.ryplazim.com/cost-support-resources/ 2026-03-26 daily 0.9 https://www.ryplazim.com/assets/images/resources-ligneous-gingivitis-caused-by-plasminogen-deficiency-type-1.png Ligneous gingivitis caused by congenital plasminogen deficiency type 1, manifesting as gum lesions https://www.ryplazim.com/assets/images/resources-respiratory-tract-lesions-in-plasminogen-deficiency-type-1-patient.png Respiratory tract lesions in plasminogen deficiency type 1 patient https://www.ryplazim.com/assets/images/resources-ligneous-conjunctivitis-caused-by-congenital-plasminogen-deficiency-type-1.png Ligneous conjunctivitis caused by congenital plasminogen deficiency type 1, manifesting as an eye lesion, prior to treatment with RYPLAZIM https://www.ryplazim.com/assets/images/resources-skin-lesions-on-arm.png Skin lesions on arm https://www.ryplazim.com/assets/images/resources-ligneous-conjunctivitis-with-multiple-white-cauliflower-like-lesions-in-upper-and-lower-eyelids.png Ligneous conjunctivitis with multiple white, cauliflower-like lesions in upper and lower eyelids https://www.ryplazim.com/assets/images/resources-otological-lesions-in-plasminogen-deficiency-type-1-patient.png Otological lesions in plasminogen deficiency type 1 patient https://www.ryplazim.com/connect-with-a-nurse-educator/ 0.9 https://www.ryplazim.com/cost-support-resources/faq/ 0.9 https://www.ryplazim.com/about-ryplazim/ 0.9 https://www.ryplazim.com/assets/images/graphic-showing-15-out-of-15.png Graphic showing 15 out of 15 https://www.ryplazim.com/assets/images/pie-charts-showing-a-78percent-reduction.png Pie charts showing a 78% reduction in external lesions and a 75% reduction in internal lesions https://www.ryplazim.com/assets/images/pie-charts-showing-a-75percent-reduction.png Pie charts showing a 78% reduction in external lesions and a 75% reduction in internal lesions https://www.ryplazim.com/assets/images/graphic-showing-zero-new-lesions.png Graphic showing zero new lesions https://www.ryplazim.com/assets/images/photos-of-ligneous-conjunctivitis-before-starting-ryplazim.png Photos of ligneous conjunctivitis before starting RYPLAZIM https://www.ryplazim.com/assets/images/photo-of-ligneous-conjunctivitis-after-starting-ryplazim.png Photos of ligneous conjunctivitis after starting RYPLAZIM https://www.ryplazim.com/assets/images/about/treatment_restarted.png Plasminogen levels https://www.ryplazim.com/about-plgd1/ 0.9 https://www.ryplazim.com/assets/images/about-plgd1/person-image.png Plasminogen Deficiency Type 1 symptoms affect the entir body https://www.ryplazim.com/assets/images/about-plgd1/8-of-10-image.png Graphic showin that 8 out of 10 people with plasminogen deficiency type 1 have multiple lesions https://www.ryplazim.com/assets/images/ligneous-gingivitis-caused-by-plasminogen-deficiency-type-1.png Ligneous gingivitis caused by congenital plasminogen deficiency type 1, manifesting as gum lesions https://www.ryplazim.com/assets/images/respiratory-tract-lesions-in-plasminogen-deficiency-type-1-patient.png Respiratory tract lesions in plasminogen deficiency type 1 patient https://www.ryplazim.com/assets/images/skin-lesions-on-arm.png Skin lesions on arm https://www.ryplazim.com/assets/images/about-plgd1/9point5-months.png Typical age at diagnosis: 9.5 months https://www.ryplazim.com/assets/images/about-plgd1/61years.png Diagnosis as late as 61 years https://www.ryplazim.com/assets/images/about-plgd1/1point6-people.png Affects an estimated 1.6 people out of a million https://www.ryplazim.com/assets/images/about-plgd1/plasminogen-logo.png Plasminogen Deficiency Foundation https://www.ryplazim.com/assets/images/about-plgd1/doctor-female-icon.png Clinical evaluation https://www.ryplazim.com/assets/images/about-plgd1/family-icon.png Plasminogen gene testing https://www.ryplazim.com/assets/images/about-plgd1/testtube-icon.png Plasminogen testing https://www.ryplazim.com/cost-support-resources/patient-stories/regan/ 0.8 https://www.ryplazim.com/cost-support-resources/patient-stories/abby/ 0.8 https://www.ryplazim.com/cost-support-resources/patient-stories/riley/ 0.8 https://www.ryplazim.com/cost-support-resources/patient-stories/heather/ 0.8 https://www.ryplazim.com/prescribing-information/ 0.8 https://www.ryplazim.com/cost-support-resources/patient-stories/renae/ 0.8 https://www.ryplazim.com/sitemap/ 0.8 https://www.ryplazim.com/cost-support-resources/patient-stories/wren/ 0.8